The Gombe State Ministry of Health (SMoH) serves as the regulatory body for the health sector. The Ministry is responsible for the development and implementation of policies and programmes to achieve the government’s health agenda that aims to improve health indices in the state. The SMoH is supported in the design and implementation of health policies by the Gombe State Primary Health Care Development Agency (GSPHCDA), which is responsible for managing the primary health care system, the Hospital Services Management Board (HSMB), which is directly responsible for coordinating the functions of secondary health facilities, and the State Contributory Health Care Management Agency (GoHealth), which offers financial risk protection through the pooling of resources for the achievement of universal health coverage. Gombe State Agency for the Control of Aids (GomSACA) and Gombe State Board of Traditional Medicine (GSBTM).

In general, the Gombe State Ministry of Health is dedicated to improving the health and well-being of the Gombe state population, with a focus on ensuring that every resident has access to quality healthcare services, regardless of their socioeconomic status or geographical location.